Volume 4, Issue 1 (1-2017)                   CMEJ 2017, 4(1): 1-6 | Back to browse issues page

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Montazer Torbati Z, Nezhadali A, Mojarrab M. Synthesis of molecularly imprinted polypyrrole for extraction and determination of fluvoxamine in serum sample using multivariable optimization methods. CMEJ. 2017; 4 (1) :1-6
URL: http://cmej.europeansp.org/article-12-129-en.html
Department of Chemistry,Payame Noor University (PNU), Mashhad, Iran
Abstract:   (1009 Views)
In this work, a novel sensor using molecularly imprinted polymer (MIP) technique for the detection of fluvoxamine was developed. The fluvoxamine imprinted polymer was prepared under the optimal conditions. Polypyrrole was synthesized chemically using ferric chloride (III) as oxidant. The polymerization was carried out at 35ºC. A Plackett–Burman design (PBD) was chosen as a screening method to estimate the relative influence of the factors that could have an influence on the analytical response (absorbance). The significant variables were optimized using central composite design (CCD). Under the optimized conditions, the calibration curve demonstrated linearity over a concentration range of 0.1 to 10 mM and 1 to 100 µM of fluvoxamine with R2 = 0.994 and 0.995 respectively. The detection limit of fluvoxamine was obtained 0.77 µM (n=7). The sensor showed a good reproducibility and regeneration capacity. The relative standard deviation (RSD %) of 4.3% was obtained to evaluate of polymer-to-polymer reproducibility. This sensor was successfully applied to the quantification of fluvoxamine in some pharmaceutical samples, human serum and plasma. © 2016 The Authors. Published by ISCDBU Inc. Selection and peer-review under responsibility of the Organizing Committee of ISCDBU.
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Type of Study: Research |
Received: 2019/08/8 | Accepted: 2019/08/8 | Published: 2019/08/8

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